Aging is a problem over which physicians and biologists have long been wrestling. In the process of aging, the functions of tissues and the organism are gradually disrupted, and involution occurs.
The first studies in the field of gerontology (aging science) were carried out at the end of the 19th century by the Russian and French biologists II. Mechnikov. He showed that increasing cellular immunity increases life expectancy. For this study in 1908, he was awarded the Nobel Prize in Physiology or Medicine in conjunction with P. Ehrlich. For the twentieth century, gerontology has moved far ahead, and today the first results of studies on slowing down of aging have already been obtained.
Vladimir Havinson develops the scientific heritage of II. Mechnikov and studies the peptide regulation of aging for 35 years . At today’s meeting, he presented the results of a complex of experimental and clinical studies.
According to the speaker, when aging, in addition to reducing immunity, there are other changes at the cellular level – the internal structure of the cell nucleus changes, the protein synthesis in the cell decreases. Professor Havinson noted that the immunodeficiency that occurs with aging is corrected with the help of endogenous regulatory peptides.
The species limit of the life span of animals and humans (the maximum possible lifespan for a given species) is approximately 30-40% higher than the average life expectancy. So, the species limit of human life is 110-120 years, while the average life expectancy is 75-80 years. This is due to the fact that various adverse factors such as stress, bad ecology, harmful radiation that lead to a change in expression (the process during which hereditary information from the gene is converted into RNA or protein) and the structure of the genes affect our body. That, in turn, is accompanied by a violation of protein synthesis and a decrease in body functions. But there are scientifically proven technologies and anti-aging drugs, which include peptide bioregulators.
Professor Havinson noted that with age, the concentration of proteins and peptides is reduced by almost 4 times. It has been proven that the action of peptides stimulates protein synthesis in the cells of those organs from which these peptides have been isolated, which ultimately increases the average life expectancy.
Also, peptides help prevent the development of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s. With neurodegenerative diseases, there is approximately one mechanism – as the cells age, spines disappear, without which the work of the neural network becomes impossible. On the example of Huntington’s disease it is proved that the action of peptides leads to the restoration of spines and a neural network.
Another discovery was the discovery of the ability of peptides to restore retinal cells and pigment epithelium, for example, in degenerative diseases of the retina in humans.
The speaker drew the attention of those present to the fact that the annual course of use of thymus preparations (“thymalin”) and epiphysis (“epithalamin”) led to a decrease in the death rate of patients during the observed period (6-12 years), which was associated with improved immune, endocrine , cardiovascular systems, brain, increased bone density.
Also, the results of 15-year clinical studies of epithalamin showed that the survival of elderly patients increased by 66.7% within the observed period.
Concluding his presentation, Professor Havinson emphasized that signal peptides play an important role in regulating gene expression, protein synthesis, and longevity, and that there is a single evolutionary epigenetic mechanism for peptidergic regulation of gene expression and protein synthesis in different species in nature.
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